个人简介

复旦大学放射医学研究所青年研究员，2008年毕业于中国科学院生物物理研究所博士，2009-2014年美国纪念斯隆凯特琳癌症研究所（MemorialSloanKetteringCancerCenter）博士后从事干细胞类器官和干细胞辐射损伤再生研究。2014年受聘复旦大学放射医学研究所，组建干细胞与再生医学实验室。中华医学会放射医学与防护学青年委员会委员。先后在国际知名杂志CancerResearch、Gastroenterology、Nature、JCI、JImmunology、JBC及Immunity上发表研究工作，得到国际同行的高度评价。

近期论文

发表论文： 1.Hua,Guoqiang#，Wang,Chu，Pan,Yan，Zeng,Zhaoshi，Lee,SangGyu，Martin,MariaLaura，Haimovitz-Friedman,Adriana，Fuks,Zvi，Paty,PhilipB，Kolesnick,RichardN#，DistinctlevelsofradioresistanceinLgr5+colonicepithelialstemcellsversusLgr5+smallintestinalstemcells.,CancerRes.2017Apr15;77(8):2124-2133.（#共通讯作者） 2.HuaGuoqiang,ThinTH,FeldmanR,Haimovitz-FriedmanA,CleversH,FuksZ,KolesnickR.CryptBaseColumnarStemCellsinSmallIntestinesofMiceAreRadioresistant.Gastroenterology.2012;143:1266-1276. HighlightedbyGastroenterology,FixingtheBreaksinIntestinalStemCellsAfterRadiation:AMatterofDNADamageandDeathorDNARepairandRegenerationGastroenterology.2012:1144-1147. 3.LindemansCA,CalafioreM,MertelsmannAM,O'ConnorMH,DudakovJA,JenqRR,VelardiE,YoungLF,SmithOM,LawrenceG,IvanovJA,FuYY,TakashimaS,HuaG,MartinML,O'RourkeKP,LoYH,MokryM,Romera-HernandezM,CupedoT,DowLE,NieuwenhuisEE,ShroyerNF,LiuC,KolesnickR,vandenBrinkMR,HanashAM,Interleukin-22promotesintestinalstemcell-mediatedepithelialregeneration,Nature.2015Dec24;528(7583):560-4 4.HanashAM,DudakovJA,HuaGuoqiang,etal.Interleukin-22ProtectsIntestinalStemCellsfromImmune-MediatedTissueDamageandRegulatesSensitivitytoGraftversusHostDisease.Immunity.2012Aug24;37(2):339-50. RotoloJ,StancevicB,ZhangJ,HuaGuoqiang,FullerJ,YinX,Haimovitz-FriedmanA,KimK,QianM,Cardó-VilaM,FuksZ,PasqualiniR,ArapW,KolesnickR.Anti-ceramideantibodypreventstheradiationgastrointestinalsyndromeinmice.JClinInvest.2012May1;122(5):1786-9. 5.GuoqiangHua,QixiangZhang,andZusenFan.HeatShockProtein75(TRAP1)AntagonizesReactiveOxygenSpeciesGenerationandProtectsCellsfromGranzymeM-mediatedApoptosis.J.Biol.Chem.,Jul2007;282:20553-20560. 6.GuoqiangHua,WangS,ZhongC,XueP,FanZ;Ignitionofp53bombsensitizestumorcellstogranzymeK-mediatedcytolysis.JImmunol.2009Feb15;182(4):2152-9. 7.LianfengWu,WangL,GuoqiangHua,LiuK,YangX,ZhaiY,BartlamM,SunF,FanZ;Structuralbasisforproteolyticspecificityofthehumanapoptosis-inducinggranzymeM.JImmunol.2009Jul1;183(1):421-9. 8.TongbiaoZhao,HonglianZhang,YumingGuo,QixiangZhang,GuoqiangHua,HongxiaLu,QiangHou,HaipingLiu,andZusenFan.GranzymeKcleavesthenucleosomeassemblyproteinSETtoinducesingle-strandedDNAnicksoftargetcells.CellDeathDiffer,Mar2007;14(3):489-99. 9.JianlingJin,GuoqiangHua,ChaoBo,etal.TheinfluenceofbacterialphysiologicalstateontheantibacterialeffectofChineseherbalmedicines.ChineseJournalofTraditionalandWesternMedicine,Jul2004.,5(13). 10.JianlingJin,YongnaLuan,GuoqiangHua,PeijiGao.Relationbetweentheantibacterialactivityofsomeherbaldrugsandtheirberberineamount.ActaChineseMedicineandPharmacology,Aug2004.,33(5):19-21. 11.李远闯#,富国祥,潘梦雪,郭强,饶欣欣,徐小雅,周轶,高建军,华国强*;小鼠肠腺瘤类器官培养及其辐射敏感性研究;复旦学报医学版,2019.1(46); 12.Li-XiaDu#,Yan-QingWang,Guo-QiangHua,Wen-LiMi*,IL-33/ST2;PathwayasaRationalTherapeuticTargetforCNSDiseases,Neuroscience,2018(369):222; 13.王楚#;高建军;华国强*,肠道类器官在精准医学中的应用,中国科学:生命科学,2017.3.3,47(2):171-179; 14.富国祥#,李远闯,潘梦雪,郭强,饶欣欣,徐小雅,周轶,邵春林,高建军,华国强*;利用肠道类器官培养研究表皮调节素的抗辐射作用;中华放射医学与防护杂志2018(38):9. 编写专著： HuaGuoqiang,KolesnickR.UsingASMaseknockoutmicetomodelhumandiseases.SphingolipidsinDiseases.2013;(216):29-54,Springer.

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